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Expression and significance of hMLH1 in carcinogenesis of esophageal mucosa epithelium

Fang Wang

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Abstract

Objective To investigate the expression and significance of hMLH1 in carcinogenesis of esophageal mucosa epithelium.Methods The expression of hMLH1 in normal esophageal mucosa epithelium and different pathological changed tissues was detected by immunohistochemistry,and its corelation with clinical pathological parameters was analysed as well.Results The positive expression rate in esophageal squamous cell carcinoma(14.29%) was significantly lower than that in normal esophageal mucosa epithelium(95.00%),atypical hyperplasia(71.43%) and carcinoma in situ(68.00%,P0.05).The positive expression of hMLH1 was correlated with the differentiation of esophageall carcinoma(P0.001).Conclusion The abnormal expression of hMLH1 protein may be related with the carcinogensis of the esophageal squamous cell,and may be an event in the early phase of it.

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What this paper is about

Objective To investigate the expression and significance of hMLH1 in carcinogenesis of esophageal mucosa epithelium.Methods The expression of hMLH1 in normal esophageal mucosa epithelium and different pathological changed tissues was detected by immunohistochemistry,and its corelation with clinical pathological parameters was analysed as well.Results The positive expression rate in esophageal squamous cell carcinoma(14.29%) was significantly lower than that in normal esophageal mucosa epithelium(95.00%),atypical hyperplasia(71.43%) and carcinoma in situ(68.00%,P0.05).The positive expression of hMLH1 was correlated with the differentiation of esophageall carcinoma(P0.001).Conclusion The abnormal expression of hMLH1 protein may be related with the carcinogensis of the esophageal squamous cell,and may be an event in the early phase of it.

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Available abstract

Objective To investigate the expression and significance of hMLH1 in carcinogenesis of esophageal mucosa epithelium.Methods The expression of hMLH1 in normal esophageal mucosa epithelium and different pathological changed tissues was detected by immunohistochemistry,and its corelation with clinical pathological parameters was analysed as well.Results The positive expression rate in esophageal squamous cell carcinoma(14.29%) was significantly lower than that in normal esophageal mucosa epithelium(95.00%),atypical hyperplasia(71.43%) and carcinoma in situ(68.00%,P0.05).The positive expression of hMLH1 was correlated with the differentiation of esophageall carcinoma(P0.001).Conclusion The abnormal expression of hMLH1 protein may be related with the carcinogensis of the esophageal squamous cell,and may be an event in the early phase of it.

Key concepts: Epithelium, Immunohistochemistry, Carcinogenesis, Pathology, Pathological, Atypical hyperplasia, Hyperplasia, Carcinoma

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