Effects of E838 in Combination with γ-ray on H22 Hepatocellular Carcinoma Cells of Mice

Objective n this study, we investigated the inhibiting effects of combination treatment E838 with γ-ray on mouse liver cancer H22. Methods 0.2ml H22 cell suspension (5×107cells/ml)were subcutaneously was injected into flanks of IRM-2 mice. The inoculated mice were invited into 5 groups: control; simple E838 groups with dose at 5, 7.5 and 10 mg/kg, daily, total 7 times; simple cytoxan groups with dose at 25 mg/kg (3 times); only irradiated with 1 Gy γ-ray and E838 combined with γ-ray group. Results The tumor inhibiting rate for E838 treated group were 50.6%, 62.73% and 54.82% respectively, there were significant difference compared with control group(P0.01). The tumor inhibiting rate for the combination group were 52.98%, 67.61% and 59.15% respectively(P0.05,compared with control group),but there were no significantly difference between E838 groups and combination groups. Conclusion These data suggest that E838 have significant inhibiting effects for inoculated tumor in mouse. The tumor inhibition rate of combination groups seems to be higher than that of E838 treatment groups, but not significantly.