Antitumor Effects of Combination Treatment of E838 with γ-ray for Mouse Lymphoma

Objective To investigate the tumor inhibitory effects of E838 and the combined antitumor effects of E838 and 137Cs γ-ray irradiation.Methods IRM-2 mice transplanted with 2～3 mm3 lymphoma(LM) tissue for 24h,were randomized into nine groups: control group,radiation group,high、middle、low E838 dose group,different dose E838 combined with radiation group and cyclophosphamide group.E838 group and combined group administered with same dose E838 daily for 7 days,cyclophosphamide group administered every other day 4 times.Combined group radiated with 1 Gy/day for 5 days after the mice wereadministered with E838 for 4 days.The size of LM tumor and the bone marrow cells of different group were measured.Results The mouse LM tumor inhibitory ratios of three E838 doses groups were(44.14±15.96)%、(70.74±11.17)% and (50.00±18.09)% respectively.There was a significant difference between E838 groups and control group(P0.001).The level of bone marrow cells counting was markedly elevated.E838 combined with 137Csγ-ray could enhance tumor inhibitory effect,the tumor inhibitory ratios of three combined groups were(65.43±2.13)%、(77.13±6.38)% and(67.55±11.17)%,there were obviously increased compare with control and radiation group respectively(P0.001).Conclusion E838 has good tumor inhibitory effects on lymphoma transplanted mice tumor.The synergistic antitumor effects was found after the mice were treated with E838 and γ-ray irradiation,the bone marrow function recovery after irradiation was speed up when the mice were administrate with E838 of some definite doses.