Donepezil hydrochloride in the treatment of vascular dementia 40 Cases

Objective To study the donepezil hydrochloride in the treatment of vascular dementia in clinical efficacy.Methods Hospital from May 2008 to May 2010 patients with vascular dementia,80 cases were randomly divided into the observation group and the control group.The control group with conventional therapy.Observation group were given treatment on the basis of 5mg donepezil hydrochloride orally,1 time / d,two groups of patients were treated for 8 weeks.Two groups of patients before and after treatment in patients with MMSE cognitive assessment of the situation;The two groups were assessed by ADL Scale activities of daily living before and after treatment.Results After 8 weeks treatment group MMSE and ADL scores compared with the control group after treatment,the difference was statistically significant,(P0.05);In improving the plasma viscosity,plasma ET-1 and serum NO concentrations in the treatment group was better than the control group.Conclusions Donepezil hydrochloride can effectively improve the vascular dementia patients with cognitive dysfunction,lower degree of dementia and improve daily living and other significant effects.