2011•Journal of Shenyang Medical CollegeRequires access

The Expression of Bcl-2 Protein after Ischemic Brain Damage in Neonatal Rat

Li Yu

Abstract

Objective:To study the effect of Bcl-2 protein in cell apoptosis by observing the expression of Bcl-2 protein in hippocampus of hypoxic ischemic brain damage(HIBD).Methods:48 neonatal rats were used in isham operated group and 7 trial groups.The models of HIBD were established in neonatal rats by inhaling the mixed gases of 92%N2 and 8%O2,and the animals were sacrificed by dislocation their heads at different time morphological analysis.Results:The positive cell of Bcl-2 protein increased after HIBD and reached the peak at 6h and then decreased gradually following HIBD.Conclusions:The expression of Bcl-2 protein in hippocampus is stronger than other areas of brain,and there is relationship between cell apoptosis and Bcl-2 protein.

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Key concepts: Brain damage, Apoptosis, Hippocampus, Protein expression, BAX Protein, Brain Cell, Programmed cell death, Cell