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Study on the expression of bcl-2 protein after hypoxic ischemic brain damage in neonatal rats

Li Yu

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Abstract

Objective:To study the effect of bcl-2 gene in cell apoptosis by observing the expression of bcl-2 gene in hippocampus of hypoxic ischemic brain damage(HIBD). Methods:Fifty-six neonatal rats were used in a control group and 7 trial groups.The models of HIBD were established in neonatal rats by inhaling the mixed gases of 92% N2 and 8%O2,and the animals were sacrificed by dislocating their heads at different time morphological analysis.Results:The positive cell of bcl-2 protein increased after HIBD and reached the peak at 6h and then decreased gradually following HIBD.Conclusion:The expression of bcl-2 gene in hippocampus is stronger than that of the other areas of brain,and there is relationship between cell apoptosis and bcl-2 gene.

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What this paper is about

Objective:To study the effect of bcl-2 gene in cell apoptosis by observing the expression of bcl-2 gene in hippocampus of hypoxic ischemic brain damage(HIBD). Methods:Fifty-six neonatal rats were used in a control group and 7 trial groups.The models of HIBD were established in neonatal rats by inhaling the mixed gases of 92% N2 and 8%O2,and the animals were sacrificed by dislocating their heads at different time morphological analysis.Results:The positive cell of bcl-2 protein increased after HIBD and reached the peak at 6h and then decreased gradually following HIBD.Conclusion:The expression of bcl-2 gene in hippocampus is stronger than that of the other areas of brain,and there is relationship between cell apoptosis and bcl-2 gene.

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Available abstract

Objective:To study the effect of bcl-2 gene in cell apoptosis by observing the expression of bcl-2 gene in hippocampus of hypoxic ischemic brain damage(HIBD). Methods:Fifty-six neonatal rats were used in a control group and 7 trial groups.The models of HIBD were established in neonatal rats by inhaling the mixed gases of 92% N2 and 8%O2,and the animals were sacrificed by dislocating their heads at different time morphological analysis.Results:The positive cell of bcl-2 protein increased after HIBD and reached the peak at 6h and then decreased gradually following HIBD.Conclusion:The expression of bcl-2 gene in hippocampus is stronger than that of the other areas of brain,and there is relationship between cell apoptosis and bcl-2 gene.

Key concepts: Brain damage, Medicine, Apoptosis, Hippocampus, Brain Cell, Gene, Gene expression, Cell

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