Expression and its clinical signification of anti-oncogene ING1 in early-stage lung carcinoma tissues

Objective To investigate the expression of p33ING1 that expressed by anti-oncogene ING1,and its relationship with clinic pathology feature in early-stage lung carcinoma tissues;and to explore the possible mechanism of anti-oncogene ING1 in the carcinogenesis of lung carcinoma.Methods Immunohistochemistry staining(labeled streptavidin-biotin method)was used to detect p33ING1 expression in 40 cases with lung carcinoma and 10 cases with normal lung tissues.Results The positive rate of p33ING1 in 40 cases with lung carcinoma tissues(57.5%,23/40)was significantly lower than that with normal lung tissues(100.0%,10/10)(P 0.05).The positive rates of p33ING1 expression were 76.2%(16/21)and 36.8%(7/19)in cancerous tissues with or without lymph node metastasis(P0.05);the positive rates of p33ING1 expression in cancerous tissue at TNM I or Ⅱ stages were significantly higher than that at TNM Ⅲ-Ⅳ stages [88.9%(8/9)vs 9.1%(1/11),70.0%(14/20)vs 9.1%(1/11)(P0.01)];the positive rates of p33ING1 expression were 87.5%(7/8),77.8%(14/18)and 14.3%(2/14)in well-differentiated,moderately-differentiated and poorly-differentiated tissues,respectively;among which the positive rates of well-differentiated and moderately-differentiated tissues were significantly higher than that in poorly-differentiated tissues(P0.01).Conclusion Expression of p33ING1 is reduced in lung carcinoma and is related to differentiation,TNM stages and lymph node metastases.Down-expression of p33ING1 is useful for evaluating malignancy degree and invasion and metastasis of lung carcinoma and might play an important role in the carcinogenesis of lung carcinoma.