Expression of L-selectin in different types of lung carcinoma and its clinical significanc

Objective:To investigate the expression of adhesion molecule L-selectin in different types of lung carcinoma and its clinical significance. Methodes: The expression of L-selectin was tested by imunohistochemical method in 110 cases of lung carcinoma specimens (40 cases of squamous cell carcinoma, 40 cases of adenocarcinoma, 30 cases of small cell carcinoma) and 30 cases of pericancerous normal lung specimens. Resultes: In 110 cases of lung carcinoma specimens, 37 cases showed positive staining of L-selectin protein (33.6%). But in 30 normal lung specimens, there was no positive cases. The positive rate of L-selectin expression in lung carcinoma specimens was significantly higher than that in normal lung specimens (P0.005). The expression rates of L-selectin in squamous cell carcinoma, adenocarcinoma and small cell carcinoma were 20.0%, 67.5% and 6.7% respectively ,there was significantly difference (P0.005). The positive rate of L-selectin expression in adenocarcinoma was significantly higher than that in squamous cell carcinoma and small cell carcinoma (P0.005). In 68 cases with lymph node metastasis and 42 cases without lymph node metastasis, the expression rates of L-selectin were 41.2% and 21.4% respectively,there was significantly difference between the two groups (P0.05). The expression rates of L-selectin in Ⅰ, Ⅱ, Ⅲ and Ⅳ stage were 21.6%,31.0%,46.2% and 80.0% respectively,there was significance dependability between expression of L-selectin and TNM stage (P0.05). The positive rates of L-selectin expression in males and females were 32.1% and 38.5% respectively (P0.05). The positive rate of L-selectin expression was 28.1% in ≤60 years group, and 41.3% in 60 years group (P0.05). Conclution: Expression of L-selectin is associated with histological type, lymph node metastasis and higher TNM stage of lung carcinoma, but is not related with of age and sex. Up-regulated expression of L-selectin is a feature of lung adenocarcinoma.