Drug resistance of extended-spectrum β-lactamases-producing escherichia coli causing respiratory tract infection in neonates

OBJECTIVE To study the characteristics of antibiotic resistance of extended-spectrum β-lactamases(ESBLs)producing Escherichia coli in newborn respiratory tract infection to guide the clinical drug application.METHODS The antibiotic resistance of E.coli to antibiotics was detected by using K-B scraps methods.ESBLs-producing strains were detected,and susceptibilities to all antibiotics were determined according to criteria of CLSI.RESULTS A total of 56 strains of ESBLs-producing bacteria were detected in 68 E.coli.Its positive rate was 82.4%.The multidrug resistance was serious in the ESBLs-producing strains E.coli.The sensitivities of ESBLs-producing E.coli to Meropenem(100.0%) and imipenem(98.2%) were the highest.CONCLUSION Carbapenems and cefoperazone/sulbactam can be the first choice in the treatment to newborn respiratory tract infection caused by ESBLs-producing E.coli.