Relationship between insulin resistance and serum levels of adiponectin,leptin and erythrocyte membrane insulin receptor in patients with gestational diabetes

Objectives To investigate changes in serum levels of adiponectin,leptin and erythrocyte membrane insulin receptor among patients with gestational diabetes (GDM),and to study their relation to insulin resistance.Methods Fasting plasma glucose (FPG),fasting serum insulin (FINS), serum levels of adiponeetin and leptin,indices of lipid metabolism,2 h plasma glucose during oral glucose tolerance test (2 h PG),2 h serum insulin during oral glucose tolerance test (2 h INS),as well as number of erythrocyte membrane insulin receptors with high and low appetency and its constants,were determined in 40 patients with GDM and 34 controls with normal glucose tolerance.Insulin resistance index (IRI) was calculated.Results ① Serum levels of leptin and adiponectin were (11.7±2.8) μg/L and (7.8±1.6) μg/L,respectively,and number of high appeteney erythrocyte membrane insulin receptor (R_1) and low appetency erythrocytemembrane insulin receptor (R_2) was (43±9) / red cell and (2297±525) / red cell,respectively.Serum level of leptin was significantly higher in those with GDM than those of normal controls (P0.05).Serum level of adipouectin,and R_1 and R_2 were significantly lower in those with GDM than those of normal controls (P0.05).② IRI was significantly higher in those with GDM than those of normal controls (P0.05).③ Linear multivariate regression analysis indicated that body mass index before pregnancy,serum levels of adiponeetin,leptin,and R_2 were independent factors that associated with IRI (P0.01).Conclusions Serum levels of adiponectin and leptin and number of insulin receptor on erythrocyte membrane may play an important role in pathogenesis of insulin resistance in pregnant women with GDM.