Relationship between gestational diabetes mellitus offspring of red cell membrane insulin receptor and insulin resistance

Objective:To investigate the relationship between gestational diabetes mellitus(GDM) offspring of red cell membrane insulin receptor and insulin resistance.Methods:Fasting blood glucose(FBG),fasting insulin(FINS),2 h postprandial blood glucose(2hBG),postprandial 2 h Insulin(2 h INS),cholesterol(TC),glycerol 3 ester(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),detection of high and low affinity of red cell membrane insulin receptor number(R1,R2) and affinity constants(K1,K2) were measured in 32 children whose mothers were gestational diabetes and 22 children whose mothers were normal pregnancy The insulin resistance index(IRI) were calculated.Results:R1and R2 in GDM group were lower than in control group(P0.05);The levels of weight,BMI,FINS in GDM group were higher than in control group(P0.05).Multiple stepwise regression analysis showed that weight(t=2.186,P0.05),BMI(t=3.362,P0.05),R1(t=-2.613,P0.05),R2(t=-2.541,P0.05) were the main risk factors affecting IR of children in GDM group.Conclusion:GDM offspring has insulin resistance,and relate closely with the red cell membrane insulin receptors,affinity and obesity.