Efficacy of irbesartan and cilazapril on heart fuction in patients with mild to moderate essetial hypertension

AIM To observe and compare efficacy and the effect of irbesartan and cilazapril on heart functions in patients with mild or moderate essential hypertension. METHODS Sixty patients with mild to moderate hypertension were treated with irbesartan 150～300 mg or cilazapril 2.5～5.0 mgdaily. For 8 weeks, sitting blood pressure, heart rate, echocardiography and laboratory examination of the patients were observed at baseline and post treatment. Adverse reactions were recorded. RESULTS After 8 weeks of treatment, efficacy was achieved in 80.0% of patients in irbesartan group and 73.3% in cilazapril group ( P 0.05). The decrease of sitting blood pressure was significant in both of the two groups ( P 0.01), irbesartan group was more significant ( P 0.05). In two groups, atiral peak filling velocity ( A ) was all decreased ( P 0.01), early peak filling velocity (E) and E/A radio were increased ( P 0.01); there were no statistical differences between irbesartan and cilazapril. Cilazapril administration induced dry coughing (10%) whereas irbesartan did not. CONCLUSION Irbesartan 150～300 mg dialy was effective in the treatment of mild to moderate essential hypertension, and can improve heart function.