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The Expression and Significance of P_(53) and PCNA Proteins in Human Colorectal Carcinoma

Jing Ta

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Abstract

Objective To study the relationship of the expression and significance of protein P(53) and proliferating cell nuclear antigen(PCNA) in colorectal carcinoma.Methods P(53) and PCNA in 50 cases of colorectal carcinoma were detected by immunohistochemistry(SP technique).Results The positive rates of P(53) and PCNA were 52.0% and 76.0% respectively.The rates of positivity for P(53) and strong positivity for PCNAA were correlated with the depth of invasion and lymph node metastasis in colorectal carcinoma.And the differences were statistically significant.Conclusion The expression of P(53) and PCNA may be related with depth of invasion,lymph node metastasis and clinical value of predicting prognosis.

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What this paper is about

Objective To study the relationship of the expression and significance of protein P(53) and proliferating cell nuclear antigen(PCNA) in colorectal carcinoma.Methods P(53) and PCNA in 50 cases of colorectal carcinoma were detected by immunohistochemistry(SP technique).Results The positive rates of P(53) and PCNA were 52.0% and 76.0% respectively.The rates of positivity for P(53) and strong positivity for PCNAA were correlated with the depth of invasion and lymph node metastasis in colorectal carcinoma.And the differences were statistically significant.Conclusion The expression of P(53) and PCNA may be related with depth of invasion,lymph node metastasis and clinical value of predicting prognosis.

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Available abstract

Objective To study the relationship of the expression and significance of protein P(53) and proliferating cell nuclear antigen(PCNA) in colorectal carcinoma.Methods P(53) and PCNA in 50 cases of colorectal carcinoma were detected by immunohistochemistry(SP technique).Results The positive rates of P(53) and PCNA were 52.0% and 76.0% respectively.The rates of positivity for P(53) and strong positivity for PCNAA were correlated with the depth of invasion and lymph node metastasis in colorectal carcinoma.And the differences were statistically significant.Conclusion The expression of P(53) and PCNA may be related with depth of invasion,lymph node metastasis and clinical value of predicting prognosis.

Key concepts: Proliferating cell nuclear antigen, Medicine, Immunohistochemistry, Colorectal cancer, Clinical significance, Lymph node metastasis, Carcinoma, Lymph node

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