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2002•Heilongjiang Medical JournalRequires access

Expression and Significance of PCNA, P~(53) and Pgp in Colorectal Carcinoma

Shu-Fan Chen

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Abstract

Objective To study the relation between the expression of PCNA, P 53 , Pgp and clinical pathological parameters in colorectal carcinoma. Methods The expression of PCNA, P 53 and Pgp were detected with immunohistochemical technique (S-P) in 235 cases of carcinoma in large intestine. Results The positive rates of PCNA, P 53 and Pgp expression were 87.2%, 74.9% and 45.9% respectively. The positive expression of PCNA and P 53 were occurred in 57.7% of the 235 cases. The positive expression of PCNA and P 53 in the tumor was correlated with clinical pathological parameters. Conclusion PCNA and P 53 might play a combined role in colorectal carcinoma occurring. Pgp had popular significance in the choice of chemotherapy for colorectal carcinoma.

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What this paper is about

Objective To study the relation between the expression of PCNA, P 53 , Pgp and clinical pathological parameters in colorectal carcinoma. Methods The expression of PCNA, P 53 and Pgp were detected with immunohistochemical technique (S-P) in 235 cases of carcinoma in large intestine. Results The positive rates of PCNA, P 53 and Pgp expression were 87.2%, 74.9% and 45.9% respectively. The positive expression of PCNA and P 53 were occurred in 57.7% of the 235 cases. The positive expression of PCNA and P 53 in the tumor was correlated with clinical pathological parameters. Conclusion PCNA and P 53 might play a combined role in colorectal carcinoma occurring. Pgp had popular significance in the choice of chemotherapy for colorectal carcinoma.

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Available abstract

Objective To study the relation between the expression of PCNA, P 53 , Pgp and clinical pathological parameters in colorectal carcinoma. Methods The expression of PCNA, P 53 and Pgp were detected with immunohistochemical technique (S-P) in 235 cases of carcinoma in large intestine. Results The positive rates of PCNA, P 53 and Pgp expression were 87.2%, 74.9% and 45.9% respectively. The positive expression of PCNA and P 53 were occurred in 57.7% of the 235 cases. The positive expression of PCNA and P 53 in the tumor was correlated with clinical pathological parameters. Conclusion PCNA and P 53 might play a combined role in colorectal carcinoma occurring. Pgp had popular significance in the choice of chemotherapy for colorectal carcinoma.

Key concepts: Proliferating cell nuclear antigen, Medicine, Pathological, Immunohistochemistry, Colorectal cancer, Clinical significance, Carcinoma, Pathology

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Expression and Significance of PCNA, P~(53) and Pgp in Colorectal Carcinoma — Research Paper | ScholarLens