ScholarLens Back to search
2005•Unpublished venueRequires access

Expression and biological behavior of P53 and PCNA in colorectal carcinoma

XU Yong-xing

Open publisher page 0 citations

Abstract

Objective To study the relationship of the expression and biological behavior of protein P53 and proliferating cell nuclear antigen(PCNA) in colorectal carcinoma.Methods P53 and PCNA in 57 cases of colorectal carcinoma were detected by immunohistochemistry(S-P technique).Results The positive rates of P53 and PCNA were 82.4% and 75.4% respectively.The rates of positivity for P53 and strong positivity for PCNAA were correlated with the depth of invasion and lymph node metastasis in colorectal carcinoma.And the differences were statistically significant(P0.05).Conclusion The expression of P53 and PCNA may be related with depth of invasion,lymph node metastasis and clinical value of predicting prognosis.

About this research paper

What this paper is about

Objective To study the relationship of the expression and biological behavior of protein P53 and proliferating cell nuclear antigen(PCNA) in colorectal carcinoma.Methods P53 and PCNA in 57 cases of colorectal carcinoma were detected by immunohistochemistry(S-P technique).Results The positive rates of P53 and PCNA were 82.4% and 75.4% respectively.The rates of positivity for P53 and strong positivity for PCNAA were correlated with the depth of invasion and lymph node metastasis in colorectal carcinoma.And the differences were statistically significant(P0.05).Conclusion The expression of P53 and PCNA may be related with depth of invasion,lymph node metastasis and clinical value of predicting prognosis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the relationship of the expression and biological behavior of protein P53 and proliferating cell nuclear antigen(PCNA) in colorectal carcinoma.Methods P53 and PCNA in 57 cases of colorectal carcinoma were detected by immunohistochemistry(S-P technique).Results The positive rates of P53 and PCNA were 82.4% and 75.4% respectively.The rates of positivity for P53 and strong positivity for PCNAA were correlated with the depth of invasion and lymph node metastasis in colorectal carcinoma.And the differences were statistically significant(P0.05).Conclusion The expression of P53 and PCNA may be related with depth of invasion,lymph node metastasis and clinical value of predicting prognosis.

Key concepts: Proliferating cell nuclear antigen, Immunohistochemistry, Colorectal cancer, Lymph node metastasis, Medicine, Carcinoma, Metastasis, Pathology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression and biological behavior of P53 and PCNA in colorectal carcinoma — Research Paper | ScholarLens