Expression and clinical significance of lung resistance-related protein in acute leukemia

OBJECTIVE:To investigate the LRP expression in acute leukemia and the relationship between the expression and clinical remission rate.METHODS:The levels of LRP were detected by monoclonal antibodies and flow cytometry in 15 normal controls and 79 patients with acute leukemia(AL),and the clinical significance of the expression rates wes evaluated.RESULTS:The expression rate of LRP in the initial acute lymphoblastic leukemia(ALL)group(29.29±6.72)% was higher than that of the acute myelogenous leukemia(AML)group(21.46±5.23)%,P=0.018 2.The expression rate of LRP in the relapse/refractory ALL group(41.18±9.06)% was significantly higher than that of the relapse/refractory AML group(30.44±11.51)%,P=0.015 4.The expression rates of LRP in the relapse/refractory AL group were significantly higher than those of the corresponding initial group,P was 0.017 5 and 0.013 8.The clinical remission rate of LRP+patients(30.8%)was lower than that of LRP-patients(77.5%),P=0.008 1.CONCLUSIONS:The expression rat of LRP in relapse/refractory patients is higher than that of initial patients.Overexpression of LRP in AL is significantly related to the clinical prognosis.