Therapeutic efficacy evaluation of intravenous metoprolol in patients with rapid atrial fibrillation

Objective To observe the efficacy and safety of intravenous metoprolol for control of ventricular rate in patients with atrial fibrillation. Methods 66 eligible patients with atrial fibrillation were randomized to 2 groups, metoprolol group(n = 34) :5 mg was injected slowly. If there is no effect in 5 minutes, it must be done again for 3 times consecutively, and the total dose was 15 mg;Cedilanid group (control group, n= 32) :0.2-0.4 mg was injected after diluted. If non - efficacious, it can be given 0.2 - 0.4 mg again for 3 times consecutively, and the total dose was 0.6 -1.0 mg. Electrocardiographic recordings and blood pressure were performed before and after drug administration. Compare the efficacy at different time points. Results Compared with the cedilanid group, metoprolol took effect faster [(8.7±3.2)min vs (38.4±10.1)min], significantly decreased in ventricular rate (35.44% vs 27.04%),and had a higher total effective rate (91.2% vs 71.9%). All patients improved without any severe side effect. Conclusion To control ventricular rate of rapid atrial fibrillation by intravenous metoprolol is rapid, safe, and efficacious.