Therapeutic efficacy of intravenous metoprolol and diltiazem in patients with rapid atrial fibrillation

Objective:To observe the efficacy and safety of intravenous metoprolol and diltiazem for control of ventricular rate in patients with atrial fibrillation.Methods:A total of 105 patients with atrial fibrillation were randomized to 3 groups:metoprolol group(n=39):treated with injected metoprolol.Diltiazem group (n=35):treated deltiazem injected;Cedilanid group (n=31):treated with cedilanid injected.Electrocardiogram and blood pressure recordings were performed before and after drug administration. The efficiencies at different time points were compared.Results:Compared with the cedilanid group, metoprolol and diltiazem took faster effect[(36.9±11.6)min∶( 8.2±4.5)min∶(9.1±3.8)min,P0.05],the ventricular rate mort decreased(P0.05),and had a higher total effective rate (71.0%∶89.7%∶91.4%, P0.05).There was no diversity between metoprolol group and diltiazem group.There was not any severe side effect in three groups.Conclusion:To control ventricular rate of rapid atrial fibrillation by intravenous metoprolol and diltiazem is rapid,safe and efficacious.