Synthesis of NM23 and P53 protein in renal cell carcinoma and its clinical significance

Aim:To study the relationship between nm23 and p53 gene expression and the carcinogenesis and the development of human renal cell carcinoma (RCC) Methods:Synthesis of NM23 and P53 protein in the cancerous tissues of 55 patients with RCC and 42 pericancerous tissues were studied with immunohistochemical methodResults:The positive rates of NM23 and P53 protein in RCC were 672% and 302% respectively There was significant negative correlation between NM23 and P53 protein positive degree(r′s=-0461,P005)Synthesis of NM23 and P53 protein wasn′t associated with size, clinical stage and pathological classification of the tumor, but was correlated with histological differention degree of the RCC and prognostic evaluation of the patients Conclusions:The results show that nm23 and p53 gene may play some roles in occuring and development of the RCC They may be useful in judging malignance of the RCC and evaluating prognosis of the patients