Expressions and significance of COX-2,EGFR and PgP in gastric cancer

Objective To investigate the expressions and clinical significance of cyclooxy-genase-2(COX-2),epidermal growth factor receptor(EGFR) and P-glycoprotein(PgP) in gastric cancer.Methods Protein expressions of COX-2,EGFR and PgP in gastric cancer were detected by immunohistochemical method in 360 patients.Relationship of COX-2,EGFR and PgP expressions with clinicopathological characteristics were analyzed.Results The positive expression rates of COX-2,EGFR and PgP in gastric cancer tissues were 83.9%,36.1% and 68.6%,respectively.The expressions of COX-2 and PgP in gastric cancer tissues were correlated to lymph node metastasis(P0.05),but not correlated to age and tumor differentiation.EGFR expression was associated with tumor invasion.PgP expression was associated with gender.Conclusion Detection of the expressions of COX-2,EGFR and PgP is valuable in evaluating the invasion and metastasis of gastric cancer.