Expression of epidermal growth factor receptor and cyclooxygenase-2 in gastric carcinoma tissues and their clinical significance

To investigate the expression of epidermal growth factor receptor(EGFR)and cyclooxygenase(COX)-2 in gastric carcinoma tissues and their clinical significance and correlation. The Envision immunohistochemical two-step method was used to detect the expression of EGFR and COX-2 in 40 cases of gastric carcinoma tissues. The positive expression rate of EGFR was 72.50%(29/40),and that of COX-2 was 52.50%(21/40).The expression of EGFR and COX-2 was significant correlated with lymph node metastasis in gastric carcinoma(P 0.05).The positive expression of EGFR and COX-2 in gastric carcinoma was correlated with its clinical stage.The positive expression of EGFR and COX-2 in patients in stage Ⅲ+Ⅳ was higher than that in stage I+II(P 0.05).The expression of EGFR was closely correlated with that of COX-2(P 0.05). The overexpression of COX-2 and EGFR participates in the pathogenesis of gastric carcinoma,and is correlated with lymph node metastasis and the clinical stage of gastric carcinoma.Positive cooperativity can be seen in the expression of EGFR and COX-2 in gastric carcinoma.