The relationship between mutant P53 accumulation and MDR-1 gene expression in gastric cancer

Objective To explore the relationship between mutant P53 and MDR-1 gene expression in gastric cancer.Methods Forty six surgical specimens of gastric cancer were examined the levels of P53 protein and p-glycoprotein(PgP) by immunohistochemical technique.Results In this study 28 of 46 samples (60.87%) were positive for P53, and 34 of 46 (73.91%) were positive for PgP.Pgp expression were detected in 23 of 28 P53-positive specimens, and in 9 of 18 P53-negative ones.There was a close correlation between P53 and PgP expression (P0.05).And the expression of PgP and P53 was closely associated with histological differentiation of the carcinoma.Conclusion The results demonstrate that PgP expression is closely associated with P53 protein accummulation in human gastric cancer.