Observation of gemcitabine combination therapy of relapsed or refractory non-Hodgkin′s lymphoma

Objective To evaluate the effect and toxicity of gemcitabine combined with oxaliplatin and dexamethasone in the treatment of relapsed or refractory of non-Hodgkin′s lymphoma.Methods 21 patients with histologically confirmed relapsed or refractory non-Hodgkin′s lymphoma were enrolled in this study.The chemotherapy regimen consisted of gemcitabine(1 000 mg/m2,iv.gtt,d1,8),oxaliplatin(100 mg/m2,iv.gtt,d2) and dexamethasone(40 mg/d,iv.gtt,d1-4) was given every three to four weeks,and every patient was treated for no less than 2 cycles.Results 16 out of the 21 patients(76.2%) showed response including 7 patients with complete response and 9 patients with partial response.The main drug related toxic effects wereⅠ-Ⅲ degree bone marrow depression and mild gastrointestina1 reactions in most patients.Conclusion The combination of gemcitabine,oxaliplatin and dexamethasone possesses better short term efficacy and acceptable toxieity.This protocol is worthy to be further confirmed as salvage for relapsed or refractory non-Hodgkin′s lymphoma.