Efficacy of GLD (gemcitabine,oxaliplatin,dexamethasone) regimen in recurrent and refractory non-Hodgkin' s lymphoma

Objeetive:To evaluate the effect and toxicity of gemcitabine combined with oxaliplatin and dexamethasone in the treatment of patients with relapsed or refractory non-Hodgkin's lymphoma.Methods: Twenty-one patients with confirmed relapsed or refractory non-Hodgkin's lymphoma were enrolled in this study.The chemotherapy regimen consisted of gemcitabine(1000 mg/m~2,day 1 and 8),oxaliplatin(85 mg/m~2,day 1 and 8) and dexamethasone(40 mg/d,day 1～4) given every three to four weeks,at least 2 cycles of chemotherapy for each patient.Results:Of 21 patients,15 patints showed response(71.43%) including 5 patients having complete response and 10 patients partial response.Drug related toxic effects were mild gastrointestinal reactions in most patients and mild bone marrow depression in few patients. Conclusion:The combination of gemcitabine,oxaliplatin and dexamethasone possesses better short term efficacy,acceptable toxicity,and obvious alleviation of symptoms related to the disease.This protocol is worthy to be warranted as salvage for relapsed or refractory non-Hodgkin's lymphoma.