Efficacy of Gemcitabine Combined with Oxaliplatin and Dexamethasone Regi-men on Relapsed or Refractory Non-Hodgkin's Lymphoma

Objective: To evaluate the efficacy and toxicity of gemcitabine combined with oxaliplatin and dexamethasone regimen for patients with relapsed or refractory Non- Hodgkin' s lymphoma. Methods: Gemcitabine 1 000 mg / m2,ivgtt on d1 and d8; oxaliplatin 130 mg / m2,ivgtt on d1; dexamethasone 20 mg/d,ivgtt,on d1 to d5; 21 ~28 days consisted of one cycle,and all the patients received over two cycles of the chemotherapy. Results: In 38 cases,the overall response rate was 68. 42%. There was a complete response in 10 cases( 26. 32%),partial response in 16 cases( 42. 10%). Main toxicity wereⅠ ~ Ⅲdegree bone marrow depression and mild gastrointestinal reactions. Conclusions: Gemcitabine combined with oxaliplatin and dexamethasone regimen was safe and effective in the treatment of relapsed or refractory Non-Hodgkin's lymphoma. Worthy of clinical application.