Sublingual with dermatophagoides farinae drops extract for allergic rhinitis

Objective To evaluate the efficacy and safety of sublingual with dermatophagoides farinae drops extract for the treatment of allergic rhinitis for 1 year.Methods 72 patients with allergic rhinitis caused by dermatophagoides farinae were enrolled in this self-contrast study.Clinical efficacy was evaluated by signs and symptoms scores and life quality scores after one year of sublingual immunotherapy and compared with pre-treatment scores.Results A clinically significant reduction in signs and symptoms scores in these 72 patients compared with those of pre-treatment was found(P0.05).The effective rate was 76.4%,All items of quality of life were improved significantly(P0.05).5 local adverse reactions including oral/sublingual swelling,sublingual tinglingnumbness and oral itching and 5 slight systemic adverse reactions occurred in total subjects,while no fatal systemic reaction occurred.Conclusion Sublingual with dermatophagoides farinae drops extract is an effective treatment for patients suffering from allergic rhinitis,individualization of dosage is recommended to improve tolerance and security.