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Clinical significance of expression of β-catenin and CDX2 in gastric carcinoma

Huang Zhi

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Abstract

AIM: To analyze the association of the expression of β-catenin and CDX2 with invasion,metastasis,and prognosis of human gastric carcinoma.METHODS: Eighty patients with gastric carcinoma and 12 normals as control were examined for the expression of β-catenin and CDX2 by SP immunohistochemistry.RESULTS: β-catenin was present in all normal gastric mucomembranous epithelium,but CDX2 was not.β-catenin was decreased,deficient,or abnormaliy distributed in gastric carcinoma tissues.These two markers were associated with the differentiation,invasion,metastasis of gastric carcinoma(P0.01).The 5-year survival rate was highest in patients with co-expression of β-catenin and CDX2(P0.05).CONCLUSION: The expression of CDX2 or β-catenin may be associated with the genesis,invasion,and metastasis of gastric carcinoma.

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AIM: To analyze the association of the expression of β-catenin and CDX2 with invasion,metastasis,and prognosis of human gastric carcinoma.METHODS: Eighty patients with gastric carcinoma and 12 normals as control were examined for the expression of β-catenin and CDX2 by SP immunohistochemistry.RESULTS: β-catenin was present in all normal gastric mucomembranous epithelium,but CDX2 was not.β-catenin was decreased,deficient,or abnormaliy distributed in gastric carcinoma tissues.These two markers were associated with the differentiation,invasion,metastasis of gastric carcinoma(P0.01).The 5-year survival rate was highest in patients with co-expression of β-catenin and CDX2(P0.05).CONCLUSION: The expression of CDX2 or β-catenin may be associated with the genesis,invasion,and metastasis of gastric carcinoma.

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Available abstract

AIM: To analyze the association of the expression of β-catenin and CDX2 with invasion,metastasis,and prognosis of human gastric carcinoma.METHODS: Eighty patients with gastric carcinoma and 12 normals as control were examined for the expression of β-catenin and CDX2 by SP immunohistochemistry.RESULTS: β-catenin was present in all normal gastric mucomembranous epithelium,but CDX2 was not.β-catenin was decreased,deficient,or abnormaliy distributed in gastric carcinoma tissues.These two markers were associated with the differentiation,invasion,metastasis of gastric carcinoma(P0.01).The 5-year survival rate was highest in patients with co-expression of β-catenin and CDX2(P0.05).CONCLUSION: The expression of CDX2 or β-catenin may be associated with the genesis,invasion,and metastasis of gastric carcinoma.

Key concepts: CDX2, Catenin, Immunohistochemistry, Gastric carcinoma, Metastasis, Medicine, Pathology, Carcinoma

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