Clinical application values of serum BDNF and NSE detections in children with febrile seizure

Objective:To explore the clinical application values of serum brain derived neurotrophic factor(BDNF) and neuron specific enolase(NSE) detections in children with febrile seizure.Methods:Forty children with febrile seizure who were treated in the hospital were selected,forty children with fever induced by respiratory tract infection and without convulsion who were treated in the hospital during the same period were selected as fever group,forty children who received physical examination in the hospital during the same period were selected as normal control group,ELISA was used to detect serum levels of BDNF and NSE in the three groups,then the results were compared and analyzed.Results:The serum levels of BDNF and NSE in febrile seizure group were statistically significantly higher than those in the other two groups(P0.05).The serum levels of BDNF and NSE in children with convulsion 5 times were statistically significantly lower than those in children with convulsion ≥5 times(P0.05).The serum levels of BDNF and NSE in children with simple convulsion were statistically significantly lower than those in children with complex convulsion(P0.05).There was a significant correlation between BDNF level and NSE level(γ=0.725,P0.05).Conclusion:BDNF and NSE can indicate the degree of brain injury,and related tests are easy,simple,and reliable,which are worthy to be popularized in clinic.