Clinical Significance of Changes of Serum NSE and PRL Levels on Brain Lesion in Simple Febrile Convulsion Children

Objective To explore the clinical detecting significance of the changes of serum neuron specific enolase(NSE)and prolactin(PRL)levels on brain lesion in children with simple febrile convulsion (SFC).Methods 35 children who were diagnosed with SFC in our hospital during January to June in 2006 were chosen as experimental group,23 children with fever but without convulsion in the same period as control group 1 and 21 healthy children as control group 2.ELISA detecting method was applied to detect NSE and PRL.Results(1)Compared with those in control group 1 and 2,the serum NSE levels in experimental group(P 0.05)was significantly different(P 0.05),but there was no visible difference between control group 1 and 2(P 0.05).(2) To compare serum PRL levels,there was no statistical significance among three groups (P 0.05).Conclusion The serum level of NSE was obvious high but the serum PRL did not change in SFC group,so it is concluded that SFC could lead to brain lesion and serum NSE level can be used as an detecting index of brain lesion.The serum PRL level is useful for distinguishing diagnoses of convulsion.