Serum neuron-specific enolase and prolactin level in children with simple febrile convulsion and its significance

Objective To investigate the change of serum neuron specific enolase(NSE)and Prolactin levels in children with simplicial febrile convulsion(SFC)and to explore its clinical significance.Methods Serum NSE and PRL were determined in 35 children with SFC,23 febrile children without convulsion and 23 healthy children.Results Compared with febrile and healthy group,the serum NSE levels in SFC group(P0.05),but there was not obvious difference between febrile and healthy group(P0.05).Serum PRL levels showed no statistically significant difference among three groups(P0.05).Conclusion NSE is a de- tectable,specific and stable marker for brain damage.Serum PRL is useful for differential diagnosis of convul- sion.SFC might be related to the pathogenesis of brain damage rather than epilepsy.