High-dose Irbesartan treatment of diabetic nephropathy clinical curative effects

Objective To observe the High-dose Irbesartan treatment diabetic nephropathy(DN) patients the effect of adenoidectomy.Methods Diabetic nephropathy(DN) patients 50 cases(envelope hair),randomly divided into the treatment group(high-dose Irbesartan group,n=25) and control group(small doses of Irbesartan group,n=25),4 weeks after comparing therapeutic effect and medication side-effects.Results Two groups of patients had lower blood pressure,but the two groups difference was statistically significant(P0.05),urinary albumin were significantly decrease(Pa0.01,Pb0.05),high-dose Irbesartan groups after treating urinary albumin decline,the effect is more significant than small dose group(P0.05).Conclusion High-dose Irbesartan application on the DN patients have independent of blood pressure outside of the renal protection effect,good safety.