2013•Chinese Journal of Clinical Rational Drug UseRequires access
Clinical effect observation of Keluoxin combined with Irbesartan in proteinuria of stage III of diabetic nephropathy
Zhou Guang-j
Open publisher page 1 citations
Abstract
Objective To observe the clinical efficacy of keluoxin combined Irbesartan in proteinuria of stage Ⅲ of diabetic nephropathy. Methods 102 cases of patients with stage Ⅲ diabetic nephropathy were randomly divided into experi- mental group( 54 cases) and control group( 48 cases). Experimental group was treated with Keluoxin combined with Irbesar- tan,Control group was treated by single Irbesartan. 8 weeks after treatment,compared the 24h urine protein and serum creati- nine,serum albumin levels of 2 groups. Results Before treatment,the level of 24h urine protein,serum creatinine and serum albumin were no statistically significant( P 0. 05). 8 weeks after treatment,the 24h urine protein of 2 groups were lower than that before treatment,the difference was statistically significant( P 0. 05). Conclusion Treating stageⅢ diabetic nephropa- thy with keluoxin combined Irbesartan is safe,and has better effectiveness than Irbesartan single. The 2 drugs play a synergistic role in the treatment of stage Ⅲ diabetic nephropathy.