Antihypertensive and Kidney Protective Effect of Irbesartan

Objective To observe the effects of angiotensin Ⅱ receptor antagonist(ARB) Irbesartan in decreasing blood pressure and protecting kidney to the patients suffering from primary hypertension combined with earlier type Ⅱ diabetic nephropathy.Methods The patients with mild to moderate primary hypertension and earlier type Ⅱ diabetic nephropathy were divided into 2 groups randomly.Group A treated with Irbesartan and group B with Amlodipine.The period of treatment and doses were adjusted depending on the blood pressure on the fourth weekend.The curative effect of the two groups was evaluated 6 months later.Results There was significant difference in the post treatment 24h urinary albumin excretion rate(UAER) and the variation of UAER between the two groups(P0.05).There were not significant difference in the effect of decreasing blood pressure,side effects and other aspects.Conclusions Irbesartan and Amlodipine have similar effects for mild to moderate primary hypertension.Irbesartan could defer effectively the development of proteinuria in diabetic nephropathy and protect the function of kidney.