Combination use of clobetasol propionate and retin-A creamin treatment of psoriasis vulgaris

Objective To evaluate the efficacy and safety of a combination use of clobetasol propionate and retin A cream in the treatment of psoriasis vulgaris. Methods A randomized controlled and double blind trial was used. 72 patients were divided into trial group(combination of clobetasol propionate and retin A cream),control group 1(Diwei cream),and control group 2(Enfu cream). The efficacy and safety were observed.Results The cure rate and efficacy rate were 58 3% (14/24) and 100 0% (24/24),respectively, for trial group whereas cure rate and efficacy rate were 41 7% (10/24) and 75 0% (18/24), respectively, for control group 1 and 16 7% (14/24) and 75 0% (18/24) for control group 2. The difference was significant between various groups ( P 0 05). There were no local and general adverse effects of drugs in all groups.Conclusion A combination use of clobetasol propionate and retin A cream is effective and safe in treatment of psoriasis vulgaris.