Smad2 protein in normal cervix, cervical intraepithelial neoplasia and cervical carcinoma expression and significance

Objective To study the Smad2 protein in normal cervix,cervical intraepithelial neoplasia and cervical invasive carcinoma,and the relationship with clinicopathological features.Methods Cervical intraepithelial neoplasia tissue sample 67 cases(CIN group),53 cases of invasive cervical cancer tissue samples(ICC group),30 cases of normal cervical tissue samples(NCE group),used immunohistochemical SP method to detect the organization of Smad2 protein.Results In normal cervix,cervical intraepithelial neoplasia and cervical carcinoma tissues Smad2 positive rate,the degree of staining score,score and percentage of positive cells express strength,the difference was statistically significant(P0.01).CIN1,CIN2,CIN3 grade Smad2 positive rate and expression intensity score,the difference were statistically significant(P0.01),the expression intensity score with cervical intraepithelial neoplasia grade were negatively correlated(P 0.05).Smad2 expression in cervical carcinoma were related to degree of differentiation,pathological grade(P0.05).Conclusion Smad2 protein in cervical carcinoma tissues than normal cervical tissue and cervical intraepithelial neoplasia tissue,Smad2 protein and cervical intraepithelial neoplasia lesions related to the de gree,and with the degree of differentiation of invasive cervical cancer and pathology grading.Smad2 protein expres sion may be low in cervical precancerous cervical lesions progress and play an important role in the occurrence and development.