The Influence of Different Doses of Mucosolvan to Lung Function of Senile Patients with Moderate to Severe AECOPD

Objective: Explore the influence with different doses of Mucosolvan injection of the lung function of senile patients who have been in Moderate to severe AECOPD(acute exacerbation of chronic obstructive pulmonary disease). Methods: Divide the 200 patients, who have been diagnosed as patients with Moderate to severe senile AECOPD by random number table method into four groups. And then inject different dose of Mucosolvan to each group patients once a day for a week. 30 mg, 90 mg, and 330 mg of Mucosolvan was injected respectively every day, and bromhexine 4 mg, 3 times/d. Then observe the changes of lung function of them, at the first day, the fourth day and the seventh day. Results: The result show that the best effect for improve lung function is the third group.And the third group changed rapidly between the first day and the fourth day, after the fourth day there was almost no improvement.However, the other three groups had almost no improvement before the fourth day, but after the seventh day they improved obviously.Conclusions: Large doses of Mucosolvan injection is good for cure Moderate to severe senile AECOPD, it safe and efficient, it also can shorten the patients' time in the hospital and reduce the patients' economic burden.