The Study of Rhubarb and Ulinastatin Combined Treatment of Severe Acute Pancreatitis

Objective To explore the effects of Rhubarb combined with Ulinastatin on severe acute pancreatitis paitents and their roles to serum levels of IL-6 and IL-8. Method 57 patients with severe acute pancreatitis were divided into three groups. On the base of normal therapy, paitents are treated with Rhubarb plus Ulinastatin in group 1(Rhubarb + Ulinastatin group, n=20), only by Ulinastatin in group 2 (Ulinastatin group, n=19), and only by normal treatment(normal treatment group, n=18). 16 healthy people from clinic were selected as blank control(blank group, n=16). The serum levels of IL-6 and IL-8 were detected by radioimmunology. The clinical index,including case fatality, effective power, catabatic duration of abdominal pain, amylase's coincidnece time and average stay time, were observed. Result Serum levels of IL-6 and IL-8 increased sharply in severe acute pancreatitis patients, which were higher than those in blank control group(P0.01). Their level decreased obviously after 5 days of all treatment group. The statistics difference was significant (P0.05). The clinical index of survivor in Rhubarb + Ulinastatin group was better than the other group (P0.05). No significant difference in fatality rate could be observed among the three groups. And the levels of IL-6 and IL-8 were lower in Rhubarb + Ulinastatin group than those in other groups (P0.05). Conclusion Maybe the combination of Rhubarb and Ulinastatin is helpful to patients to recover from severe acute in early stage.