Distribution and drug resistance of pathogenic bacteria causing biliary tract infections

OBJECTIVE To investigate distribution and drug resistance of pathogenic bacteria isolated from bile specimens obtained from the patients with biliary tract infections so as to provide basis for reasonable clinical use of antibiotics.METHODS The pathogenic bacteria,which were isolated from the bile specimens obtained from the patients who underwent biliary tract surgery from Mar 2010 to Feb 2012,were retrospectively analyzed,then the drug resistance was observed.RESULTS A total of 416 strains of pathogens were isolated,including 323(70.65%)strains of gram-negative bacilli,89(21.39%)strains of gram-positive cocci,and 4(0.96%)strains of fungi;the Escherichia coli(44.95%),Klebsiella pneumoniae(9.62%)and Pseudomonas aeruginosa(5.05%)ranked the top three species of gram-negative bacilli;the Enterococcus faecium(11.54%)and Enterococcus faecalis(6.97%)were the most common species of gram-positive cocci.The drug susceptibility rates of the E.coli and K.pneumoniaeto imipenem and meropenem were 100.0%;the drug susceptibility rate of the E.coli to cefoperazone-sulbactam was 99.47%,the K.pneumoniae 95.0%;the positive rate of ESBLs-producing E.coli was 63.64%,the ESBLs-producing K.pneumoniae 52.50%;the drug susceptibility rates of the P.aeruginosato amikacin and cefoperazone-sulbactam were 100.0%.The drug resistance rate of the Enterococcus faecalis was significantly lower than that of the Enterococcus faecium,and the drug susceptibility rates to linezolid and teicoplanin were 100.00% and 96.55%,respectively;no vancomycin-resistant Enterococci strains were detected.CONCLUSION The E.coli,Enterococci,and K.pneumoniae are the most common species of pathogens causing biliary tract infections;it is necessary for the hospital to reasonably use antibiotics based on the result of drug susceptibility testing so as to reduce the drug resistant strains and improve the cure rate.