Treatment of Chronic Hepatitis B with Oxymatrine Injection in Combination with Lamivudine

Objective:To survey the effect of oxymatrine injection combined with lamivudine in the treatment of chronic hepatitis B.Methods:80 patients with chronic hepatitis B(CHB) were randomly divided into two equal groups. Patients of the treatment group were given each 400 mg of oxymatrine injection, I.M. q.d. and 100 mg of lamivudine, PO q.d. while those of the control group were given each 100 mg of lamivudine, PO q.d. alone. The course of treatment in both groups lasted 12～24 weeks. Changes in liver function, serum markers of HBV and indices of hepatic fibrosis before and after the treatment were kept under observation. Results:Liver function of patients in both groups was found to improve dramatically. The rates of serum turning negative for HBV DNA were 90.0% and 85.0% in the treatment group and control group, respectively( P 0.05). The rates of serum turning negative for HBeAg, however, were 47.5% and 27.5% in the treatment group and control group, respectively( P 0.05). lndices of hepatic fibrosis including serum concelntrations of hyalurorhic acid(HA), procollagen type Ⅲ(PCⅢ), collagen type Ⅳ(CⅣ) and laminin(LN) were markedly lowered. The differences were significant in both groups when compared with those parameters before the treatmnet( P 0.05). Serum levels of HA and C Ⅳ were lower in the treatment group than in the control group( P 0.05) after the treatment. Conclusion:Oxymatrine injection combined with lamivudine was found to improve liver function, exert synergistic antiviral effect and promote the process of antifibrosis in the treatment of chronic hepatitis B.