Combined Application of Oxymatrine and Lamivudine in Treating 62 Cases of Chronic Hepatitis B

Objective To analyze and evaluate the application effect of oxymatrine combined with lamivudine in treating chronic hepatitis B. Methods 124 patients with chronic hepatitis B in our hospital from December 2009 to June 2011 were randomly divided into two groups. 62 cases in the observation group were treated with oxymatrine conbined with lamivudine, and 62 cases in the control group were treated with lamivudine alone. The curative effect and adverse reactions in the two groups were observed and compared. Results Patients in both goups had the symptoms of weakness, abdominal distension, anorexia and liver area discomfort and completely disappeared within one month; there was no significant difference between the two groups of patients (P 0.05). The HBeAg negative rate and HBV-DNA negative rate in the observation group were higher than those in the control group with statistical significance (P 0.05). The serum ALT recovery rate after treatment in the observation group was slightly higher than that in the control group, but the difference between two groups had no statistical significance (P 0.05). The results of blood and urine routine examination and renal function tests in both groups did not reveal the presence of abnormal. Conclusions The combined application of oxymatrine and lamivudine in treating chronic hepatitis B has ideal curative effect and no obvious adverse reactions during the treatment. The short-term curative effect is certain, while the long-term efficacy still needs further observation.