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2007•The Journal of Medical Theory and PracticeRequires access

Effects of Curcumin on Proliferation and Apoptosis of Human Ovarian Cancer Cell Line HO-8910 in vitro

Wen Yuk

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Abstract

Objective:To investigate the effects of curcumin on proliferation and apoptosis of human ovarian cancer cell line HO-8910 in vitro.Methods: The human ovarian cancer cell line HO-8910 was cultured to logarithm growing period and treated with curcumin of different concentration(5μmol/L、10μmol/L、20μmol/L、40μmol/L、80μmol/L).The inhibition rates of cells were detected through MTT assay;the apoptosis rates of cells was tested by flow cytometry;the expression of PCNA in HO-8910 cell was observed by SABC imunohistochemistry.Results:Curcumin inhibited the proliferation of HO-8910 cells in a dose-and time-dependent manner.The tumor cell apopotic rate in curcumin group was significantly higher than those in control group.The expression of PCNA was increased in a dose dependent manner.Conclusion:The curcumn not only inhibits proliferation,but also induces apoptosis of human ovarian cancer cell line HO-8910.

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Objective:To investigate the effects of curcumin on proliferation and apoptosis of human ovarian cancer cell line HO-8910 in vitro.Methods: The human ovarian cancer cell line HO-8910 was cultured to logarithm growing period and treated with curcumin of different concentration(5μmol/L、10μmol/L、20μmol/L、40μmol/L、80μmol/L).The inhibition rates of cells were detected through MTT assay;the apoptosis rates of cells was tested by flow cytometry;the expression of PCNA in HO-8910 cell was observed by SABC imunohistochemistry.Results:Curcumin inhibited the proliferation of HO-8910 cells in a dose-and time-dependent manner.The tumor cell apopotic rate in curcumin group was significantly higher than those in control group.The expression of PCNA was increased in a dose dependent manner.Conclusion:The curcumn not only inhibits proliferation,but also induces apoptosis of human ovarian cancer cell line HO-8910.

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Available abstract

Objective:To investigate the effects of curcumin on proliferation and apoptosis of human ovarian cancer cell line HO-8910 in vitro.Methods: The human ovarian cancer cell line HO-8910 was cultured to logarithm growing period and treated with curcumin of different concentration(5μmol/L、10μmol/L、20μmol/L、40μmol/L、80μmol/L).The inhibition rates of cells were detected through MTT assay;the apoptosis rates of cells was tested by flow cytometry;the expression of PCNA in HO-8910 cell was observed by SABC imunohistochemistry.Results:Curcumin inhibited the proliferation of HO-8910 cells in a dose-and time-dependent manner.The tumor cell apopotic rate in curcumin group was significantly higher than those in control group.The expression of PCNA was increased in a dose dependent manner.Conclusion:The curcumn not only inhibits proliferation,but also induces apoptosis of human ovarian cancer cell line HO-8910.

Key concepts: Curcumin, Apoptosis, Proliferating cell nuclear antigen, Cell growth, Flow cytometry, Cell culture, Medicine, In vitro

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Effects of Curcumin on Proliferation and Apoptosis of Human Ovarian Cancer Cell Line HO-8910 in vitro — Research Paper | ScholarLens