Treatment of 52 Cases of Malignant Pleural Effusion with Bleomycin

Objective:To study the therapeutic effect iveness of intrapleural administration of bleomycin in the treatment of maligant pleural effusion. Methods:52 patients with malignant pleural effusion served as subjects of the study. After the pleural effusion had been drained off as fully as possible by needle aspiration or trocar puncture, the patients were given each an intrapleural inyection of bleomycin at a dose of 30～40 mg·(m 2) 1 , once weekly, each patient receive 1 or 2 times. The therapeutic effectiveness and adverse reactions were kept under observation. Results:The overall effective rate was 82.7%(CR=26, PR=17, NC=9). The main adverse reactions including fever, chest pain and nausea were generally tolerable. Conclusion:The therapy is fairly effective in the management of malignant pleural effusion. Adverse readions are mild and tolerable.