Comparative analysis on seven detection systems for testing of fresh plasma glucose
Luo Xiu-lin
Abstract
Luo Xiu-lin
Abstract
Objective To evaluate comparability of different detection systems for determination of blood glucose through bias estimation and method comparison,and ensure the clinical quality requirements.Methods Compared with OLYMPUS AU2700 dection system,50 cases of fresh blood plasma samples were detected glucose with different detcetion systems,including electrochemical method,dry chemical method and spectrophotometric method.Results The variation coefficient of different detection systems was less than 5.0%;The correlation coefficient between the various systems was more than 0.975;The overall difference between systems was not statistically significant(P0.01);Compared with a traceable target detection system 1,Detection system 3,detection system 4,and detection system 7 exceeded the range of T ± 5%,Detection system 2,detection system 5,and detection system 6 were in the range of T ± 5% in the three medical decision levels.Conclusion There are bias in part of the different detection systems for glucose detection results,but the results are comparable through corrective measures.
A significance statement is not available in the OpenAlex record.
A contribution statement is not available in the OpenAlex record.
Method details are not available in the OpenAlex metadata.
Findings are not separately available in the OpenAlex metadata.
Limitations are not available in the OpenAlex metadata.
Application details are not available in the OpenAlex metadata.
Objective To evaluate comparability of different detection systems for determination of blood glucose through bias estimation and method comparison,and ensure the clinical quality requirements.Methods Compared with OLYMPUS AU2700 dection system,50 cases of fresh blood plasma samples were detected glucose with different detcetion systems,including electrochemical method,dry chemical method and spectrophotometric method.Results The variation coefficient of different detection systems was less than 5.0%;The correlation coefficient between the various systems was more than 0.975;The overall difference between systems was not statistically significant(P0.01);Compared with a traceable target detection system 1,Detection system 3,detection system 4,and detection system 7 exceeded the range of T ± 5%,Detection system 2,detection system 5,and detection system 6 were in the range of T ± 5% in the three medical decision levels.Conclusion There are bias in part of the different detection systems for glucose detection results,but the results are comparable through corrective measures.
Key concepts: Detection limit, Coefficient of variation, Correlation coefficient, Chromatography, Comparability, Computer science, Chemistry, Statistics