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Reversal effect of tetrandrine on multidrug resistance of the KBV200 cell line

Ye Lin

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Abstract

Objective:To study the reversal effect of tetrandrine on multidrug resistance of KBV200 cell line in order to provide experimental data for clinical individual chemotherapy.Methods:MTT reduction assay was used to investgate the inhibition of Adriamycin on KBV200cell line,and the reversal effects of Tetrandrine and Verapamil on the cell line.Results:Verapamil and Tetrandrine had the reveral effects on the cell line,and the reversal indexes of Tetrandrine and Veramil were 22.96 and 9.31,respectively.Conclusion:KBV200 cell line was multidrug resistance to Adriamycin but Tetrandrine had reversal effects on its multidrug resistance.

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What this paper is about

Objective:To study the reversal effect of tetrandrine on multidrug resistance of KBV200 cell line in order to provide experimental data for clinical individual chemotherapy.Methods:MTT reduction assay was used to investgate the inhibition of Adriamycin on KBV200cell line,and the reversal effects of Tetrandrine and Verapamil on the cell line.Results:Verapamil and Tetrandrine had the reveral effects on the cell line,and the reversal indexes of Tetrandrine and Veramil were 22.96 and 9.31,respectively.Conclusion:KBV200 cell line was multidrug resistance to Adriamycin but Tetrandrine had reversal effects on its multidrug resistance.

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Available abstract

Objective:To study the reversal effect of tetrandrine on multidrug resistance of KBV200 cell line in order to provide experimental data for clinical individual chemotherapy.Methods:MTT reduction assay was used to investgate the inhibition of Adriamycin on KBV200cell line,and the reversal effects of Tetrandrine and Verapamil on the cell line.Results:Verapamil and Tetrandrine had the reveral effects on the cell line,and the reversal indexes of Tetrandrine and Veramil were 22.96 and 9.31,respectively.Conclusion:KBV200 cell line was multidrug resistance to Adriamycin but Tetrandrine had reversal effects on its multidrug resistance.

Key concepts: Tetrandrine, Multiple drug resistance, Verapamil, Pharmacology, Cell culture, Medicine, Drug resistance, Biology

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