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[Reversal of adriamycin or vincristine resistance by tetrandrine in human cancer cells in vitro].

Zhijian Ye, Ao Sun, Li Li, X Cao, Wen‐Cai Ye

Abstract

In an in vitro culture system of human cancer cells MCF-7 and its adriamycin-resistant line MCF-7/Ad or KB and its vincristine-resistant line KBv200, tetrandrine was found to exhibit significantly selective anticancer activity against the drug-resistant cancer cell MCF-7/Ad. In addition, essentially complete reversal effects of tetrandrine on drug resistance were observed in MCF/Ad or KBv200.

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Key concepts: Tetrandrine, In vitro, Vincristine, Cell culture, Cancer cell, Pharmacology, Drug resistance, Cancer cell lines