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Effects of propofol on gastric ischemia-reperfusion injury in rats

DU Xiao-ju

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Abstract

Objective To investigate the effect of propofol on gastric ischemia-reperfusion injury (GI-RI). Methods Sprague-Dawley rats were randomly divide into 3 groups: Sham-operation group, GI/RI control group, and GI/R plus propofol group. A rat model of GI-RI was established by clamping the celiac artery for 30 min and allowing reperfusion for l h, on which gastric mucosa damage index, the activity of superoxide dismutase (SPD) and the content of malondialdehyde (MDA) of gastric mucosa were investigated. Results Propofol obviously attenuated gastric mucosa injury induced by gastric ischemia-reperfusion and reduced the gastric mucosal damage index (GMDI). From the comparison of GI/R plus propofol group with GI/RI control group, propofol obviously attenuated the GI-RI, increased the activity of SOD but decreased the content of MDA of gastric mucosa. Conclusions [WTBZ]Proporol has the protective effects on GI-RI by its anti-oxidation.

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Objective To investigate the effect of propofol on gastric ischemia-reperfusion injury (GI-RI). Methods Sprague-Dawley rats were randomly divide into 3 groups: Sham-operation group, GI/RI control group, and GI/R plus propofol group. A rat model of GI-RI was established by clamping the celiac artery for 30 min and allowing reperfusion for l h, on which gastric mucosa damage index, the activity of superoxide dismutase (SPD) and the content of malondialdehyde (MDA) of gastric mucosa were investigated. Results Propofol obviously attenuated gastric mucosa injury induced by gastric ischemia-reperfusion and reduced the gastric mucosal damage index (GMDI). From the comparison of GI/R plus propofol group with GI/RI control group, propofol obviously attenuated the GI-RI, increased the activity of SOD but decreased the content of MDA of gastric mucosa. Conclusions [WTBZ]Proporol has the protective effects on GI-RI by its anti-oxidation.

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Available abstract

Objective To investigate the effect of propofol on gastric ischemia-reperfusion injury (GI-RI). Methods Sprague-Dawley rats were randomly divide into 3 groups: Sham-operation group, GI/RI control group, and GI/R plus propofol group. A rat model of GI-RI was established by clamping the celiac artery for 30 min and allowing reperfusion for l h, on which gastric mucosa damage index, the activity of superoxide dismutase (SPD) and the content of malondialdehyde (MDA) of gastric mucosa were investigated. Results Propofol obviously attenuated gastric mucosa injury induced by gastric ischemia-reperfusion and reduced the gastric mucosal damage index (GMDI). From the comparison of GI/R plus propofol group with GI/RI control group, propofol obviously attenuated the GI-RI, increased the activity of SOD but decreased the content of MDA of gastric mucosa. Conclusions [WTBZ]Proporol has the protective effects on GI-RI by its anti-oxidation.

Key concepts: Propofol, Malondialdehyde, Gastric mucosa, Ischemia, Medicine, Reperfusion injury, Superoxide dismutase, Anesthesia

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