2009•Acta Academiae Medicinae XuzhouRequires access
Effect of ischemic post-conditioning on ischemia/reperfusion-induced injury to the free radicals in gastric mucosa in rats
Dongshu Du
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Abstract
Objective To investigate the effects and mechanism of ischemic post-conditioning on gastric ischemia-reperfusion (GI/R)-induced injury in rats. Methods 18 Sprague-Dawley rats were randomly divided into 3 groups:the normal group,the GI/R group and the I-postC group. The gastric mucosal damage index (GMDI) and the inhibitory effect of gastric mucosa on hydroxyl free radicals as well as the expression of xanthane oxidase (XOD),malondialdehyde (MDA) and superoxide dismutase (SOD) were measured respectively. Results The gastric mucosa was markedly injured after GI/R. Compared with GI/R group,I-postC evidently lessened gastric mucosal damage and enhanced the ability of gastric mucosa against hydroxyl free radicals and up-regulated the expression of SOD and down-regulated the expression of XOD and MDA. Conclusion I-postC can significantly protect against GI/R injury,and the protective mechanism is related to the inhibitory effect of I-postC against free radicals.