Relationship of the serum CA 125 of the levels with Child-pugh classification of liver cirrhosis and quantity of ascites

Objective To study the relationship of the levels serum CA 125 with Child-pugh classification of liver cirrhosis and quantity of ascites.Methods A total of 103 patients were studied,including 36 in Child-pugh A, 39 in B ,28 in C.There were 55 patients with ascites and 48 without ascites.The levels of serum CA 125 were measured in all patients and in 42 normal persons by ELISA.Results The levels of serum CA 125 in liver cirrhosis patients were significantly higher than that in controls (P 0.01).The results showed the levels of serum CA 125 in Child-pugh C in B in A,increased gradually with aggravating lesion of the liver( P 0.01).The levels of serum CA 125 in liver cirrhosis with ascites group and with small amount ascites group were significantly higher than that without ascites group(P 0.01).The levels of serum CA 125 in liver cirrhosis with middle amount ascites group sig-nificandy higher than with small amount ascites group (P 0.01).There were no statistical significant difference in the levels of serum CA 125 between large amount ascites group and middle amount ascires group.Conclusion The levels of serum CA 125 in liver cirrhosis patients have a osculating correlation with lesion of the liver and ascites degree, may serve as a sensitive marker for liver lesion degree and monitoring ascites quantity,and are of value to early diagnosis and estimating prognosis for liver cirrhosis patients with ascites.