The Ethological Improving and the Effect on Morphological Structure of Hippocampus CA_1 Neuron of DiHuang Compound in Treating Model Rats of Alzheimer's Disease(AD)

Objective:To explore the learning and memory improving and the effect on morphological structure of hippocampus CA1 neuron of DiHuang compound in treating model rats of Alzheimer's Disease(AD).Methods:Injecting D-galactose in rats' abdominal cavity to doat them,then injecting quinolinic acid(QA) in rats' hippocampus to make the mode of senile idiot,given aqueous solution of DiHuang compound by gavage,to observe the learning and memory ethological improving in Morris water maze and the shape change by optical microscope and electron microscope.Results:DiHuang compound can obviously reduce the latency of AD rats in Morris water maze,increase the platform quadrant journey ratio and the times of crossing platform,reduce the damage of hippocampus CA1 neuron,prevent the excessive loss of quantity of neuron.Conclusion:DiHuang compound could ameliorate the behaviour deficits and protect the damaged neurons of AD rats models and remedy the damaged synapse to a certain extent.