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Effects of Dihuang Compound on Learning and Memory of Rats and Apoptosis of Hippocampal Cells in Alzheimer' s Disease

Jincai Hou

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Abstract

Objective To observe the effects of Dihuang compound on learning and memory and apoptosis of hippocampus cells in Alzheimer' s disease (AD) rats. Methods AD pathological model was made by stereotactic mini injection of quinolinicacid(QA) into hippocampal CA1 area, the rat′ s learning and memory functions were evaluated by Morris water maze, the apoptosis of hippocampal cells was detected by using Tunnel, flow cytometry and electronic microscope.Results Dihuang compound(DC) was shown to improve the learning and memory deficiency in rats with bilateral hippocampal lesions induced by QA and to decrease apoptosis rate in hippocampal cells significantly.Conclusion Protective effects of Dihuang compound on AD rats may be related to its ability to decrease apoptosis rate of hippocampal cells.

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What this paper is about

Objective To observe the effects of Dihuang compound on learning and memory and apoptosis of hippocampus cells in Alzheimer' s disease (AD) rats. Methods AD pathological model was made by stereotactic mini injection of quinolinicacid(QA) into hippocampal CA1 area, the rat′ s learning and memory functions were evaluated by Morris water maze, the apoptosis of hippocampal cells was detected by using Tunnel, flow cytometry and electronic microscope.Results Dihuang compound(DC) was shown to improve the learning and memory deficiency in rats with bilateral hippocampal lesions induced by QA and to decrease apoptosis rate in hippocampal cells significantly.Conclusion Protective effects of Dihuang compound on AD rats may be related to its ability to decrease apoptosis rate of hippocampal cells.

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Available abstract

Objective To observe the effects of Dihuang compound on learning and memory and apoptosis of hippocampus cells in Alzheimer' s disease (AD) rats. Methods AD pathological model was made by stereotactic mini injection of quinolinicacid(QA) into hippocampal CA1 area, the rat′ s learning and memory functions were evaluated by Morris water maze, the apoptosis of hippocampal cells was detected by using Tunnel, flow cytometry and electronic microscope.Results Dihuang compound(DC) was shown to improve the learning and memory deficiency in rats with bilateral hippocampal lesions induced by QA and to decrease apoptosis rate in hippocampal cells significantly.Conclusion Protective effects of Dihuang compound on AD rats may be related to its ability to decrease apoptosis rate of hippocampal cells.

Key concepts: Hippocampal formation, Apoptosis, Hippocampus, Morris water navigation task, Neuroscience, Flow cytometry, Pathological, Alzheimer's disease

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Effects of Dihuang Compound on Learning and Memory of Rats and Apoptosis of Hippocampal Cells in Alzheimer' s Disease — Research Paper | ScholarLens